تأثیر فعالیت آیزوکینتیک درونگرا-درونگرا با محدودیت جریان خون بر مقدار VEGF سرم در مردان سالمند فعال | ||
| نشریه فیزیولوژی ورزش و فعالیت بدنی | ||
| دوره 14، شماره 1 - شماره پیاپی 27، فروردین 1400، صفحه 49-58 اصل مقاله (443.85 K) | ||
| نوع مقاله: علمی - پژوهشی | ||
| شناسه دیجیتال (DOI): 10.52547/joeppa.14.1.49 | ||
| نویسندگان | ||
| مریم نورشاهی* 1؛ سجاد احمدی زاد1؛ فاطمه ایمانی1؛ پونه دهقان2 | ||
| 1گروه علوم زیستی ورزش، دانشکده علوم ورزشی و تندرستی، دانشگاه شهید بهشتی، تهران، ایران | ||
| 2مرکز تحقیقات بالینی بیمارستان آیتالله طالقانی، تهران، ایران | ||
| چکیده | ||
| هدف: سالمندی فرایند کاهش پیشروندة عوامل فیزیولوژیکی و عملکردی است. از تغییرات مهم این دوره، کاهش آنژیوژنز است. براساس نتایج تحقیقات بسیاری فعالیت‌های ورزشی می‌تواند از پیشرفت این عوامل جلوگیری کند. بنابراین هدف از این مطالعه بررسی تأثیر فعالیت آیزوکینتیک درونگرا (شدت پایین) با محدودیت جریان خون بر مقدار VEGF سرم در مردان سالمند فعال است. روش‌ها: بدین‌منظور 10 نفر از مردان سالم 60-80 سالة واجد شرایط، در یکی از پارک‌های تهران به‌صورت در دسترس (میانگین وزن 25/9±8/77 کیلوگرم، قد 92/2±9/175 سانتی‌متر، شاخص تودۀ بدنی 70/2±12/25 کیلوگرم بر مترمربع) انتخاب شدند. سپس برای به‌دست آوردن 50 درصد حداکثر فشار خون انسدادی برای جلسة محدودیت جریان خون به‌وسیلة دستگاه داپلر انجام گرفت. آزمودنی‌ها 4 نوبت فعالیت فلکشن و اکستنشن زانو را با 20 درصد یک تکرار بیشینه و با سرعت زاویه‌ای 30 درجه در ثانیه حرکت فلکشن و اکستنشن پا را به‌صورت کامل انجام دادند، به‌صورتی که ابتدا نوبت اول با 30 تکرار و 3 نوبت دیگر را با 15 تکرار و با 30 ثانیه استراحت بین هر نوبت اجرا کردند. قبل از شروع پروتکل، بلافاصله و دو ساعت پس از فعالیت خون‌گیری انجام گرفت و VEGF سرم به روش الایزا اندازه‌گیری شد. برای تجزیه‌وتحلیل داده‌ها پس از اطمینان از توزیع طبیعی آنها از آنووای مکرر 3×2 استفاده شد. نتایج: نتایج تجزیه‌وتحلیل داده‌ها نشان داد که سطوح سرمی VEGF، در پاسخ به فعالیت آیزوکنتیک درونگرا همراه با محدودیت جریان خون نسبت به فعالیت آیزوکنتیک درونگرا بدون محدودیت جریان خون، افزایش معناداری داشت (0/01=P). نتیجه‌گیری: به‌نظر می‌رسد در افراد سالمند استفاده از روش محدودیت جریان خون با وجود پایین بودن شدت فعالیت بر مقدار VEGF سرم به‌عنوان یکی از عوامل رگ‌زایی در مردان سالمند فعال تأثیر بسزایی داشت. | ||
| کلیدواژه‌ها | ||
| سالمندی؛ فعالیت آیزوکینتیک؛ محدودیت جریان خون؛ VEG | ||
| عنوان مقاله [English] | ||
| The effect of concentric-concentric isokinetic activity with restricted blood flow on serum VEGF levels in active elderly men | ||
| نویسندگان [English] | ||
| Maryam Nourshahi1؛ Sajad Ahmadizad1؛ fatemeh imani1؛ Poone Dehghan2 | ||
| 1Department of Sports Life Sciences, Faculty of Sports and Health Sciences, Shahid Beheshti University, Tehran, Iran | ||
| 2Clinical Research Center of Ayatollah Taleghani Hospital, Tehran, Iran | ||
| چکیده [English] | ||
| Purpose: Aging is a process of progressive reduction of physiological and functional factors. One of the important changes that occur during this period is the reduction of angiogenesis. Many studies have shown that sports activities can prevent the development of these factors. Therefore, the purpose of this study was to investigate the effect of concentric isokinetic activity (low intensity) with blood flow restriction on serum VEGF levels in active elderly men. Methods: For this purpose, 10 healthy men at age range 60-80 years were selected through convenience sampling in a Tehran-based park (average weight: 77.8 ± 9.25 kg, height: 175.9 ± 2.92 cm, BMI: 25.15 ± 2.85kg/m2). Blood flow restriction was performed with a Doppler device to obtain 50% of the maximum restricted blood pressure for the session. Subjects performed four knee flexion and extension activities with 20% of one-repetition maximum and at an angular velocity of 30 degrees per second, complete flexion and extension of the leg. initially, they performed the first time with 30 repetitions and the other three times with 15 repetitions and with 30 seconds rest between each time. Before the start of the protocol, blood sampling was performed immediately and two hours after the activity, and serum VEGF was measured by ELISA. 2 × 3 repeated measures ANOVA was used to analyze the data after ensuring their normal distribution. Results: The results of data analysis showed that serum levels of VEGF, in response to concentric isokinetic activity with restricted blood flow, increased significantly compared to concentric isokinetic activity without restricted blood flow (P= 0.01). Conclusion: Therefore, it seems that in the elderly, the use of the blood flow restriction method, despite the low intensity of activity, had a significant effect on serum VEGF levels as one of the angiogenic factors in active elderly men. | ||
| کلیدواژه‌ها [English] | ||
| Isokinetic activity, Blood flow restriction, VEGF, Elderly | ||
| مراجع | ||
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