Synthesize of Sodium Alginate Hydrogel from Iranian Brown Seaweed as a Candidate for Biomedical Applications | ||
| Plant, Algae, and Environment | ||
| دوره 8، شماره 2، 2024، صفحه 1493-1504 اصل مقاله (426.95 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.48308/jpr.2024.237506.1093 | ||
| نویسندگان | ||
| Moein Ziyazadeh1؛ Hamide Ehtesabi1؛ Mohammad Mahdi Ahadian* 2 | ||
| 1Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran | ||
| 2Center for Nanoscience & Nanotechnology, Institute for Convergence Science and Technology (ICST), Sharif University of Technology, Tehran, Iran | ||
| چکیده | ||
| Hydrogels, which are cross-linked networks of hydrophilic polymers, are considered promising candidates for various biomedical applications due to their unique physical and chemical properties. This property is especially beneficial in applications such as drug delivery, where ease of administration is crucial. Among these materials, alginate, a natural polysaccharide derived from brown seaweed, can form hydrogels through ionic cross-linking under mild conditions without the need for toxic reagents, making it a popular choice in biomedical fields. A primary source of alginates is brown seaweed, scientifically classified under the group Phaeophyceae. Alginates are polysaccharides that are abundantly found in the cell walls of these brown seaweed species. In this research, brown algae were systematically harvested from the Oman Sea in southern Iran. After collection, the alginate was meticulously extracted and purified process to ensure its quality and suitability for medical applications. A hydrogel primarily composed of purified sodium alginate was then developed. Various techniques were utilized to evaluate the properties of the resulting hydrogel, including detailed assessments of its physical and morphological characteristics through Fourier transform infrared spectroscopy, X-ray diffraction, gel fraction analysis, and rheological studies. To determine the safety and compatibility of the synthesized hydrogel for biomedical applications, a cytotoxicity test was conducted. The results of these studies indicate that the synthesized hydrogel holds considerable promise as a candidate for biomedical applications, particularly in targeted therapies, thereby opening avenues for future research in biomedicine and pharmaceutical innovation. As the field continues to evolve, the implications of this study underscore the importance of exploring natural biopolymers for sustainable biomedical applications | ||
| کلیدواژهها | ||
| Nizamuddinia Zarnardinii؛ Biopolymer؛ Algin؛ Alginic acid؛ Hydrogel | ||
| مراجع | ||
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